Stereotactic guidance for breast biopsy was first described in Sweden in the 1970s and pioneered in the United States in the 1990s. Today, this procedure is used to obtain a histological diagnosis of a mammographic abnormality that would otherwise warrant an open surgical biopsy or to help stage a lesion that is deemed "highly-suggestive" of malignancy. In this program, we will discuss the different elements of this procedure, from principals of stereotaxis to postbiopsy; in other words, from start to finish.